SILICON PHOTOMULTIPLIER CURRENT AND PROSPECTIVE APPLICATIONS IN BIOLOGICAL AND RADIOLOGICAL PHOTONICS

Authors

  • Marialisa Stagliano Scuola di Ingegneria, Università di Pisa, Pisa, Italy
  • Francesco d’Errico Yale School of Medicine, New Haven, USA
  • Luis Abegão Yale School of Medicine, New Haven, USA
  • Andrea Chierici Istituto Nazionale di Fisica Nucleare, Pisa, Italy

DOI:

https://doi.org/10.53555/eijse.v4i4.143

Keywords:

silicon photomultipliers, photodetectors, optical biosensors, optical radiation measurements, scintillation detector

Abstract

The detection of low-intensity light is a crucial issue in many aspects of science and technology. So far, the solution has involved extremely delicate and somewhat bulky devices, the photomultiplier tubes, providing high sensitivity but suffering from fragility and susceptibility to interference. The silicon photomultiplier (SiPM) is a solid-state photon detector that provides a new solution for a wide range of photometry applications in fields as diverse as medicine, biology, environmental science, chemistry, physics, and nuclear physics. SiPMs are on a par with conventional photomultiplier tubes (PMT) in terms of internal gain and photon detection efficiency, while they are undoubtedly superior in terms of mechanical robustness, compact size, electronic stability, low power consumption, and affordability. Our group has long been involved in ionizing radiation measurements based on light emitting sensors both for industrial nuclear technology applications and for hybrid diagnostic imaging techniques. In both cases, SiPMs offer the unquestionable advantages described in this review.

References

. Perumal, V. and U. Hashim, Advances in biosensors: Principle, architecture and applications. Journal of Applied Biomedicine, 2014. 12(1): p. 1-15.

. Newell, A., Nonlinear optics. 2018: CRC Press.

. Abegão, L.M., et al., Second-and third-order nonlinear optical properties of unsubstituted and mono-substituted chalcones. Chemical Physics Letters, 2016. 648: p. 91-96.

. Santos, F.A., et al., Bromo-and chloro-derivatives of dibenzylideneacetone: Experimental and theoretical study of the first molecular hyperpolarizability and two-photon absorption. Journal of Photochemistry and Photobiology A: Chemistry, 2018.

. Kamada, K., et al., Boron Difluoride Curcuminoid Fluorophores with Enhanced Two‐Photon Excited Fluorescence Emission and Versatile Living‐Cell Imaging Properties. Chemistry–A European Journal, 2016. 22(15): p. 5219-5232.

. Abegão, L.M., et al., Oxazole Dyes with Potential for Photoluminescence Bioprobes: A Two-Photon Absorption Study. The Journal of Physical Chemistry C, 2018. 122(19): p. 10526-10534.

. Bui, A.T., et al., Cationic two-photon lanthanide bioprobes able to accumulate in live cells. Inorganic chemistry, 2016. 55(14): p. 7020-7025.

. Miao, F., et al., Novel fluorescent probes for highly selective two-photon imaging of mitochondria in living cells. Biosensors and Bioelectronics, 2014. 55: p. 423-429.

. Baugh, L.M., et al., Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease. Nature biomedical engineering, 2017. 1(11): p. 914.

. Knoll, G.F., Radiation detection and measurement. 2010: John Wiley & Sons.

. Souza, L., et al., Dosimetric properties of MgB4O7: Dy, Li and MgB4O7: Ce, Li for optically stimulated luminescence applications. Radiation Measurements, 2017. 106: p. 196-199.

. Souza, S., et al., OSL films for in-vivo entrance dose measurements. Radiation Measurements, 2017. 106: p. 644-649.

. Valença, J., et al., Optically stimulated luminescence of borate glasses containing magnesia, quicklime, lithium and potassium carbonates. Radiation Physics and Chemistry, 2017. 140: p. 83-86.

. d’Errico, F. and A. Di Fulvio, Advanced readout methods for superheated emulsion detectors. Review of Scientific Instruments, 2018. 89(5): p. 053304.

. d’Errico, F., et al., Optical readout of superheated emulsions. Radiation Measurements, 2008. 43(2-6): p. 432-436.

. Saveliev, V., Silicon photomultiplier-new era of photon detection, in Advances in Optical and Photonic Devices. 2010, InTech.

. Dautet, H., et al., Photon counting techniques with silicon avalanche photodiodes. Applied optics, 1993. 32(21): p. 3894-3900.

. Golovin, V. and V. Saveliev, Novel type of avalanche photodetector with Geiger mode operation. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2004. 518(1-2): p. 560-564.

. Somov, S.V., I. Tolstukhin, and A.S. Somov, Application of the silicon photomultipliers for detectors in the GlueX experiment. Physics Procedia, 2015. 74: p. 74-80.

. Barbosa, F., et al., Silicon photomultiplier characterization for the GlueX barrel calorimeter. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2012. 695: p. 100-104.

. Kovaltchouk, V., et al., Comparison of a silicon photomultiplier to a traditional vacuum photomultiplier. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2005. 538(1-3): p. 408-415.

. Sciuto, E.L., et al., Photo-physical characterization of fluorophore Ru (bpy) 3 2+ for optical biosensing applications. Sensing and Bio-Sensing Research, 2015. 6: p. 6771.

. Shin, Y.-H., et al., A hand-held fluorescent sensor platform for selectively estimating green algae and cyanobacteria biomass. Sensors and Actuators B: Chemical, 2018. 262: p. 938-946.

. Grigoriev, E., et al., Silicon photomultipliers and their bio-medical applications. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2007. 571(1-2): p. 130-133.

. Stortz, G., et al., Performance of a PET Insert for High-Resolution Small-Animal PET/MRI at 7 Tesla. J Nucl Med, 2018. 59(3): p. 536-542.

. Stoykov, A., et al., A SiPM-based ZnS: 6LiF scintillation neutron detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2015. 787: p. 361-366.

. Braga, L.H.C., et al., A Fully Digital 8$,times,$16 SiPM Array for PET Applications With Per-Pixel TDCs and Real-Time Energy Output. IEEE Journal of Solid-State Circuits, 2014. 49(1): p. 301-314.

. Kim, J.H., H.M. Park, and K.S. Joo, Development of compact and real-time radiation detector based on SiPM for gamma-ray spectroscopy. Journal of Instrumentation, 2018. 13(07): p. P07018-P07018.

. Ferocino, E., et al., High throughput detection chain for time domain optical mammography. Biomedical optics express, 2018. 9(2): p. 755-770.

. Farina, A., et al., Time-Domain Functional Diffuse Optical Tomography System Based on Fiber-Free Silicon Photomultipliers. Applied Sciences, 2017. 7(12): p. 1235.

. Santangelo, M.F., et al., Integrating printed microfluidics with silicon photomultipliers for miniaturised and highly sensitive ATP bioluminescence detection. Biosens Bioelectron, 2018. 99: p. 464-470.

. Santangelo, M.F., et al., Si Photomultipliers for Bio-Sensing Applications. IEEE Journal of Selected Topics in Quantum Electronics, 2016. 22(3): p. 335-341.

. Schaart, D.R., et al., Advances in digital SiPMs and their application in biomedical imaging. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2016. 809: p. 31-52.

. Mazzillo, M., et al., Silicon photomultiplier technology at STMicroelectronics. IEEE Transactions on Nuclear Science, 2009. 56(4): p. 2434-2442.

. Bocci, V., et al. The ArduSiPM a compact trasportable software/hardware data acquisition system for SiPM detector. In Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2014 IEEE. 2014. IEEE.

. Eckert, P., et al., Characterisation studies of silicon photomultipliers. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2010. 620(2-3): p. 217-226.

. Piatek, S.S., Physics and Operation of an MPPC. Hamamatsu Corporation and New Jersey Institute of Technology, 2014.

. Barbarino, G., et al., Silicon photo multipliers detectors operating in geiger regime: an unlimited device for future applications, in Photodiodes-World Activities in 2011. 2011, InTech.

. Buzhan, P., et al., Silicon photomultiplier and its possible applications. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2003. 504(1-3): p. 48-52.

. Dolgoshein, B., et al., Status report on silicon photomultiplier development and its applications. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2006. 563(2): p. 368-376.

. Hawkes, R., et al. Silicon photomultiplier performance tests in magnetic resonance pulsed fields. in Nuclear Science Symposium Conference Record, 2007. NSS'07. IEEE. 2007. IEEE.

. Frach, T., et al. The digital silicon photomultiplier—Principle of operation and intrinsic detector performance. in Nuclear Science Symposium Conference Record (NSS/MIC), 2009 IEEE. 2009. IEEE.

. Garutti, E. and Y. Musienko, Radiation damage of SiPMs. arXiv preprint arXiv:1809.06361, 2018.

. Diblen, F., et al., Radiation hardness of dsipm sensors in a proton therapy radiation environment. IEEE Transactions on Nuclear Science, 2017. 64(7): p. 1891-1896.

. Luka, G., et al., Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications. Sensors (Basel), 2015. 15(12): p. 30011-31.

. Fernández Gavela, A., et al., Last advances in silicon-based optical biosensors. Sensors, 2016. 16(3): p. 285.

. Chien, P.J., et al., Optical isopropanol biosensor using NADH-dependent secondary alcohol dehydrogenase (S-ADH). Talanta, 2016. 159: p. 418-424.

. Vasilantonakis, N., et al., Refractive index sensing with hyperbolic metamaterials: strategies for biosensing and nonlinearity enhancement. Opt Express, 2015. 23(11): p. 14329-43.

. Wu, X., et al., Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano, 2016. 10(1): p. 1060-6.

. Vasquez, E.S., et al., Bioluminescent magnetic nanoparticles as potential imaging agents for mammalian spermatozoa. J Nanobiotechnology, 2016. 14: p. 20.

. Santangelo, M., et al. CY5 fluorescence measured with silicon photomultipliers. in Biomedical Circuits and Systems Conference (BioCAS), 2014 IEEE. 2014. IEEE.

. Dey, D. and T. Goswami, Optical biosensors: a revolution towards quantum nanoscale electronics device fabrication. J Biomed Biotechnol, 2011. 2011: p. 348218.

. Jiang, S., et al., Ultra-low noise and exceptional uniformity of SensL C-series SiPM sensors, in Optical Components and Materials XII. 2015.

. Renna, L., et al., Extremely integrated device for high sensitive quantitative biosensing. Sensors and Actuators B: Chemical, 2015. 209: p. 1011-1014.

. Petralia, S., et al., Sulfide Species Optical Monitoring by a Miniaturized Silicon Photomultiplier. Sensors (Basel), 2018. 18(3).

. Wang, Y., et al., Lithium and lithium ion batteries for applications in microelectronic devices: A review. Journal of Power Sources, 2015. 286: p. 330345.

. Thielen, M., et al., Human body heat for powering wearable devices: From thermal energy to application. Energy conversion and management, 2017. 131: p. 44-54.

. Goodman, J.W., Some fundamental properties of speckle. JOSA, 1976. 66(11): p. 1145-1150.

. Ruaro, B., et al., Laser speckle contrast analysis: a new method to evaluate peripheral blood perfusion in systemic sclerosis patients. Ann Rheum Dis, 2014. 73(6): p. 1181-5.

. Milstein, D.M., et al., Laser speckle contrast imaging identifies ischemic areas on gastric tube reconstructions following esophagectomy. Medicine (Baltimore), 2016. 95(25): p. e3875.

. Hashimoto, R., T. Sugiyama, and T. Maeno, Comparison of Optic Nerve Head Blood Flow Autoregulation among Quadrants Induced by Decreased Ocular Perfusion Pressure during Vitrectomy. Biomed Res Int, 2017. 2017: p. 6041590.

. Luft, N., et al., Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy. PLoS One, 2016. 11(12): p. e0168190.

. Gasparini, L., et al. SiPM in g (2) measurements. in Quantum Information and Measurement. 2017. Optical Society of America.

. Buzhan, P., et al., Large area silicon photomultipliers: Performance and applications. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2006. 567(1): p. 78-82.

. Kuper, K., et al., On reachable energy resolution of SiPM based scintillation counters for X-ray detection. Journal of Instrumentation, 2017. 12(01): p. P01001.

. Grodzicka-Kobylka, M., et al., Study of n-γ discrimination by zero-crossing method with SiPM based scintillation detectors. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2018. 883: p. 159-165.

. Nikl, M. and A. Yoshikawa, Recent R&D trends in inorganic single‐crystal scintillator materials for radiation detection. Advanced Optical Materials, 2015. 3(4): p. 463-481.

. Tomanin, A., et al., Characterization of a cubic EJ-309 liquid scintillator detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2014. 756: p. 45-54.

. Pavlov, N., G. Mashlum, and D. Meier. Gamma spectroscopy using a silicon photomultiplier and a scintillator. in Nuclear Science Symposium Conference Record, 2005 IEEE. 2005. IEEE.

. Grodzicka-Kobylka, M., et al., Silicon photomultipliers in scintillation detectors used for gamma ray energies up to 6.1 MeV. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017. 874: p. 137-148.

. Garutti, E., et al., Silicon Photomultiplier characterization and radiation damage investigation for high energy particle physics applications. Journal of Instrumentation, 2014. 9(03): p. C03021.

. Park, J.H., et al. Analysis of changes in environmental radiation, and three types of environmental radiation detector performance comparisons. in Advancements in Nuclear Instrumentation Measurement Methods and their Applications (ANIMMA), 2013 3rd International Conference on. 2013. IEEE.

. Nodari, B., et al. Radon fast detection and environmental monitoring with a portable wireless system. in Advances in Sensors and Interfaces (IWASI), 2015 6th IEEE International Workshop on. 2015. IEEE.

. Buzhan, P., A. Karakash, and Y. Teverovskiy, Silicon Photomultiplier and CsI (Tl) scintillator in application to portable H*(10) dosimeter. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017.

. Foster, M. and D. Ramsden. A compact neutron detector based on the use of a SiPM detector. in Nuclear Science Symposium Conference Record, 2008. NSS'08. IEEE. 2008. IEEE.

. Osovizky, A., et al., Design of an ultrathin cold neutron detector. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2018. 893: p. 1-9.

. Osovizky, A., et al., SENTIRAD—An innovative personal radiation detector based on a scintillation detector and a silicon photomultiplier. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2011. 652(1): p. 41-44.

. Moutinho, L., et al., Development of a scintillating optical fiber dosimeter with silicon photomultipliers. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2014. 735: p. 640-643.

. Hudin, N., et al., Characterization and Optimization of silicon photomultipliers for the development of intraoperative beta probes. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2012. 695: p. 242-246.

. Stendahl, J., et al., Development and Testing of an Integrated Catheter for Beta Detection and Intramyocardial Therapeutic Delivery. Journal of Nuclear Medicine, 2016. 57(supplement 2): p. 1949-1949.

. Garcia-Parra, R., et al., Performance of beta-and high-energy gamma probes for the detection of cancer tissue in experimental surgical resection beds. Annals of nuclear medicine, 2011. 25(7): p. 486-493.

. Dolinsky, S., G. Fu, and A. Ivan, Timing resolution performance comparison of different SiPM devices. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2015. 801: p. 11-20.

. Hutton, B.F., K. Erlandsson, and K. Thielemans, Advances in clinical molecular imaging instrumentation. Clinical and Translational Imaging, 2018. 6(1): p. 31-45.

. Del Guerra, A., et al., Silicon Photomultipliers (SiPM) as novel photodetectors for PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2011. 648: p. S232-S235.

. Omidvari, N., et al., MR-compatibility assessment of MADPET4: a study of interferences between an SiPM-based PET insert and a 7 T MRI system. Physics in Medicine & Biology, 2018. 63(9): p. 095002.

. Bruschini, C., et al., A Sensor Network Architecture for digital SiPM Based PET Systems. IEEE Transactions on Radiation and Plasma Medical Sciences, 2018.

. Carminati, M., et al., SPECT/MRI INSERT Compatibility: Assessment, Solutions and Design Guidelines. IEEE Transactions on Radiation and Plasma Medical Sciences, 2018.

. Conti, M., Focus on time-of-flight PET: the benefits of improved time resolution. European journal of nuclear medicine and molecular imaging, 2011. 38(6): p. 11471157.

. Seifert, S., et al., First characterization of a digital SiPM based time-of-flight PET detector with 1 mm spatial resolution. Physics in Medicine & Biology, 2013. 58(9): p. 3061.

. Kwon, S.I. and J.S. Lee, Signal encoding method for a time-of-flight PET detector using a silicon photomultiplier array. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2014. 761: p. 39-45.

. Bohn, P., et al., Radiation damage studies of silicon photomultipliers. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2009. 598(3): p. 722-736.

. Li, S.-H., et al., OSL dating of sediments from deserts in northern China. Quaternary Geochronology, 2007. 2(1-4): p. 23-28.

. Arnold, L.J. and R.G. Roberts, Stochastic modelling of multi-grain equivalent dose (De) distributions: Implications for OSL dating of sediment mixtures. Quaternary Geochronology, 2009. 4(3): p. 204-230.

. Lewis, C.J., et al., Climatic implications of correlated Upper Pleistocene glacial and fluvial deposits on the Cinca and Gállego Rivers (NE Spain) based on OSL dating and soil stratigraphy. Global and Planetary Change, 2009. 67(3-4): p. 141152.

. Lomax, J., A. Hilgers, and U. Radtke, Palaeoenvironmental change recorded in the palaeodunefields of the western Murray Basin, South Australia–new data from single grain OSL-dating. Quaternary Science Reviews, 2011. 30(5-6): p. 723-736.

. Stone, A., M. Bateman, and D. Thomas. Dating large linear dunes in the southern Namib using OSL: single aliquot regeneration protocol and portable reader measurements. In EGU General Assembly Conference Abstracts. 2014.

. Pázmándi, T. and S. Deme. Space dosimetry with the application of 3D silicon telescope and Pille onboard TLD device. In Proceedings of the International Youth Nuclear Congress, Toronto. 2004.

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2018-12-27